abstract：BACKGROUND:Phosphate control is a crucial treatment goal in end-stage renal disease, but poor patient adherence to phosphate binder therapy remains a challenge. This study aimed to estimate the extent of phosphate binder adherence in hemodialysis patients and to identify potential determinants. METHODS:Phosphate binde...

journal_title：Journal of nephrology

authors： Van Camp YP,Vrijens B,Abraham I,Van Rompaey B,Elseviers MM

更新日期：2014-12-01 00:00:00

abstract：:A definite epidemiological association exists between kidney stone disease and arterial hypertension, but the pathophysiological mechanisms are still not fully understood. Hypercalciuria or inflammation and oxidative stress have been proposed as possible links. However, there is more convincing evidence that the assoc...

journal_title：Journal of nephrology

authors： Cupisti A,D'Alessandro C,Samoni S,Meola M,Egidi MF

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Inadvertent sodium (Na(+)) flux may occur during renal replacement therapy (RRT) in ICU. The objective of this study was to estimate sodium flux during RRT. METHODS:Between September 2011 to December 2012 we studied 60 ICU patients receiving extended daily dialysis (EDD, Fresenius 4008S) or continuous renal...

journal_title：Journal of nephrology

authors： Bihari S,Taylor S,Bersten AD

更新日期：2014-08-01 00:00:00

abstract：:The metabolic syndrome is a cluster of cardiometabolic alterations at least partly dependent on reduced insulin sensitivity and hyperinsulinemia that can have several renal implications. A systematic review and meta-analysis of studies available in the international literature in English language demonstrates that the...

journal_title：Journal of nephrology

authors： Rendina D,De Filippo G,D'Elia L,Strazzullo P

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Chronotropic incompetence (CI) is an independent predictor of cardiovascular events and overall mortality. The prevalence and significance of CI in renal transplant patient has not been examined. METHODS:38 non-heart failure renal transplant recipients were recruited for a transthoracic echocardiogram and t...

journal_title：Journal of nephrology

authors： Ma MK,Zuo ML,Yap DY,Mok MM,Kwan LP,Chan GC,Siu DC,Chan TM

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Uromodulin (Tamm-Horsfall protein) is the most abundant urinary protein in healthy individuals. Despite 60 years of research, its physiological role remains rather elusive. Familial juvenile hyperuricemic nephropathy and medullary cystic kidney disease Type 2 are autosomal dominant tubulointerstitial nephrop...

journal_title：Journal of nephrology

authors： Dinour D,Ganon L,Nomy LI,Ron R,Holtzman EJ

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:We aimed to evaluate the relationship between abdominal aortic calcification (AAC) and renal resistive index (RRI), parameters associated with cardiovascular outcome, in non-dialysis chronic kidney disease (CKD) patients. METHODS:Seventy-seven stable patients mainly in CKD stages 3B and 4 (44 and 28%), medi...

journal_title：Journal of nephrology

authors： Stefan G,Capusa C,Stancu S,Petrescu L,Nedelcu ED,Andreiana I,Mircescu G

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Uremic pruritus as a symptom that affects hemodialysis (HD) patients can decrease the quality of life and increase morbidity in these patients. The aim of this study was to evaluate the effects of turmeric on uremic pruritus in HD patients. SUBJECTS AND METHODS:This was a double-blind placebo-controlled tri...

journal_title：Journal of nephrology

authors： Pakfetrat M,Basiri F,Malekmakan L,Roozbeh J

更新日期：2014-04-01 00:00:00

abstract：:Replacement of dietary saturated fat with unsaturated fat has been recommended for prevention of cardiovascular disease (CVD) in the general population. Less is known of the health risks in individuals with chronic kidney disease (CKD), of a diet with an unhealthy fat profile, in general characterized by insufficient ...

journal_title：Journal of nephrology

authors： Huang X,Lindholm B,Stenvinkel P,Carrero JJ

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Proteinuria results from increased glomerular permeability and is associated with retraction and effacement of the highly specialized interdigitating podocyte foot processes. In podocytes (glomerular epithelial cells [GECs]), p130Cas localizes diffusely to the cytoplasm and connects focal adhesion proteins a...

journal_title：Journal of nephrology

authors： Ha TS,Choi JY,Park HY,Han GD

更新日期：2013-09-01 00:00:00

abstract：:Aortic intimal sarcoma is a rare tumor with poor prognosis. The most common manifestations are thromboembolic phenomena and vascular obstruction. We present a case of aortic intimal sarcoma causing bilateral renal artery stenosis which manifested as resistant hypertension and acute kidney inury. Multiple attempts to s...

journal_title：Journal of nephrology

authors： Sethi S,Pothineni NK,Syal G,Ali SM,Krause MW

更新日期：2013-09-01 00:00:00

abstract：:During Fabry disease, progressive glycosphingolipid deposition in the kidney causes gradual deterioration of renal function with proteinuria, uremia and hypertension. This results in end-stage renal disease (ESRD) which is one of the leading causes of morbidity and premature mortality in affected patients. Given the e...

journal_title：Journal of nephrology

authors： Cybulla M,Kurschat C,West M,Nicholls K,Torras J,Sunder-Plassmann G,Feriozzi S

更新日期：2013-07-01 00:00:00

abstract：:The analysis of the urinary proteome is a potential source of information regarding the kidney's physiopathology. A clear knowledge of the protein composition of normal urine is an essential prerequisite to looking at its pathology. Technological evolution in the field of proteomics (2-dimensional [2D] electrophoresis...

journal_title：Journal of nephrology

authors： Santucci L,Candiano G,Bruschi M,Bodria M,Murtas C,Petretto A,Ghiggeri GM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Accumulating experimental and clinical evidence reveals beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) in kidney disease by modulating inflammation and fibrosis mechanisms that lead to renal failure. METHODS:EPA, DHA (n-3 PUFAs) and AA (n-6 PUFA) effects, compared to those of AngII, on renal ...

journal_title：Journal of nephrology

authors： Priante G,Musacchio E,Valvason C,Clari G,Bordin L,Sartori L,Baggio B

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:No study has evaluated the efficacy of non-calcium-containing phosphate binders in slowing progression of cardiac valve calcification or deterioration of kidney function in patients with chronic kidney disease not on dialysis. This study addressed these issues. METHODS:Outpatients (n = 170) with stage 3-4 c...

journal_title：Journal of nephrology

authors： Di Lullo L,Floccari F,Santoboni A,Barbera V,Rivera RF,Granata A,Morrone L,Russo D

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:HERMEX is a population-based study which tries to evaluate the relative weight of cardiovascular risk factors in inhabitants of Extremadura, Spain. This report presents the data about chronic kidney disease (CKD) in a Spanish population sample. METHODS:For an observational cross-sectional population-based s...

journal_title：Journal of nephrology

authors： Robles NR,Felix FJ,Fernandez-Berges D,Perez-Castán JF,Zaro MJ,Lozano L,Alvarez-Palacios P,Garcia-Trigo A,Tejero V,Morcillo Y,Hidalgo AB

更新日期：2013-07-01 00:00:00

abstract：:Kidney remodeling is a response to intrinsic or extrinsic triggers of kidney injury. Injury initiates a set of universal response programs that were positively selected through evolution to control potentially life-threatening dangers and to regain homeostasis, including tissue repair. These danger control programs ar...

journal_title：Journal of nephrology

authors： Migliorini A,Ebid R,Scherbaum CR,Anders HJ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Contrast-induced nephropathy (CI-AKI) is a complication of diagnostic/therapeutic hemodynamic procedures in cardiology, which may also cause renal cholesterolinic atheroembolism. Despite the 
severe clinical impact of these complications, there is no optimal therapy for preventing and treating them. We sugge...

journal_title：Journal of nephrology

authors： Ribichini F,Gambaro A,Pighi M,Pesarini G,Ferraro PM,Zuppi C,Baroni S,Penitente R,Ferrero V,Vassanelli C

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Reduced bone mineral density (BMD) is common in end-stage renal disease (ESRD) patients and predicts outcomes. The chronic kidney disease-mineral bone disorder contributes to low BMD in ESRD; however, the impact of classical risk factors for osteoporosis in the general population, such as body weight and fat...

journal_title：Journal of nephrology

authors： Park SH,Jia T,Qureshi AR,Bárány P,Heimbürger O,Larsson TE,Axelsson J,Stenvinkel P,Lindholm B

更新日期：2013-05-01 00:00:00

abstract：:One of the major concerns in organ transplantation is the early detection of humoral rejection, through improved diagnostic and prognostic biomarkers. Long-term survival of renal allografts is significantly lower in recipients developing donor-specific anti-HLA antibodies (DSAs) either pretransplant or posttransplant....

journal_title：Journal of nephrology

authors： Zito A,Schena A,Grandaliano G,Gesualdo L,Schena FP

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:This study was undertaken to examine whether there is an association between parity and age at first birth and risk of death from chronic renal failure (CRF). STUDY DESIGN:Prospective cohort study. SETTING AND PARTICIPANTS:The study cohort consisted of 1 292 462 women who had a first and singleton childbir...

journal_title：Journal of nephrology

authors： Kuo CC,Lee CT,Chen CC,Tsai SS,Yang CY

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:In biopsy-proven idiopathic nephrotic syndrome (INS), immunoglobulin M (IgM) and C1q are occasionally deposited in the mesangium. In pediatric nephrology, the significance of mesangial IgM or C1q deposits is controversial, based on previous reports. The aim of this study was to explore the clinical significa...

journal_title：Journal of nephrology

authors： Kanemoto K,Ito H,Anzai M,Matsumura C,Kurayama H

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Mesangial proliferative glomerulonephritis (MePGN) is characterized by excessive mesangial cell proliferation and mesangial matrix expansion, which lead to glomerular sclerosis and obliteration and, in turn, to deteriorating renal function. To identify and quantify the total proteins in renal tissues of MePG...

journal_title：Journal of nephrology

authors： Sui W,Tang D,Zou T,Zou G,Chen J,Li H,Li L,Hou Y,Li H,Dai Y

更新日期：2013-01-01 00:00:00

abstract：:Reduced glomerular filtration rate and albuminuria do not account for the total risk of developing end-stage renal disease (ESRD), suggesting that other factors might be involved in progressive renal function worsening. Among these, cardiovascular disease, even subclinical, could play a role. The role of left ventricu...

journal_title：Journal of nephrology

authors： Paoletti E

更新日期：2012-11-01 00:00:00

abstract：:Hemolytic uremic syndrome (HUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. It is usually secondary to infections by strains of Escherichia coli (STEC) that produce Shiga-like toxin. In about 10% of patients, no STEC infections are reported. In these ...

journal_title：Journal of nephrology

authors： Valoti E,Alberti M,Noris M

更新日期：2012-11-01 00:00:00

abstract：INTRODUCTION:We measured serum creatinine concentrations in 17 male athletes of the Italian national rugby team. METHODS:Blood was obtained before the start of training and during the competitive season. Serum creatinine level was measured by Jaffé reaction at 4 time points during the season, with a formal measure of ...

journal_title：Journal of nephrology

authors： Banfi G,Sloand J,Shelly M,Del Fabbro M,Barassi A,Melzi d'Eril GV

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Reset osmostat (RO) occurs in 36% of patients with syndrome of inappropriate antidiuretic hormone secretion (SIADH) and is not often considered when evaluating hyponatremic patients. Patients with RO are not usually treated, but recent awareness that symptoms are associated with mild hyponatremia creates a t...

journal_title：Journal of nephrology

authors： Imbriano LJ,Ilamathi E,Ali NM,Miyawaki N,Maesaka JK

更新日期：2012-09-01 00:00:00

abstract：:The increase in progressive kidney disease, rising numbers of patients with end-stage renal disease, organ shortages for kidney transplants and poor long-term graft survival rates underline the need for better strategies to diagnose, prevent and treat renal disease. Histological analysis, based on renal biopsies and r...

journal_title：Journal of nephrology

authors： Mueller TF,Mas VR

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Drug-related problems (DRPs) are common in chronic kidney disease (CKD) patients. We developed a 2-step consultation including a clinical pharmacist (CP) session and a nephrologist conventional care consultation to explore the feasibility of a pilot drug-oriented disease management program in controlling iat...

journal_title：Journal of nephrology

authors： Belaiche S,Romanet T,Allenet B,Calop J,Zaoui P

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Peritonitis is the major cause of peritoneal dialysis (PD) technique failure. Prophylactic topical antibiotics have been reported to reduce peritoneal dialysis catheter exit site infections (ESI) and peritonitis rates. METHODS:We audited the effect of different exit site practices in the 12 P...

journal_title：Journal of nephrology

authors： Davenport A,Pan Thames Renal Audit Peritoneal Dialysis Group.

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The therapeutic effects of immunosuppressive agents such as cyclosporin A, mycophenolate mofetil, rituximab and sirolimus on primary focal segmental glomerulosclerosis (FSGS) remain controversial. The present study was intended to review and analyze the treatment results of immunosuppressive agents for prima...

journal_title：Journal of nephrology

authors： Xu S,Xu G,Zeng L

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Changes in podocyte phenotype and function are characteristic of proteinuric glomerular diseases. Integrin-linked kinase (ILK) functions as a common downstream effector in proteinuric diseases. In addition, ILK was shown to interact with the Wnt signaling pathway. Here, we investigated ILK expression as well...

journal_title：Journal of nephrology

authors： Naves MA,Requião-Moura LR,Soares MF,Silva-Júnior JA,Mastroianni-Kirsztajn G,Teixeira VP

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:During potassium (K) depletion, many adaptive responses are likely mediated through a complex network that involves expression of a variety of genes. We identified that the Nrf2 gene was differentially expressed between normal and K-depleted rat kidney. METHODS:To investigate the effect of Nrf2 on colonic...

journal_title：Journal of nephrology

authors： Lee CB,Lee YS,Lee JY,Lee SE,Ahn KY

更新日期：2012-03-01 00:00:00

abstract：:Structural and functional alterations affecting the aging kidney predispose to an increased risk of acute renal failure (ARF) in the elderly. This is a common problem becoming more relevant because of an increase in life expectancy. The epidemiology of ARF in the elderly is far from being well assessed, because of the...

journal_title：Journal of nephrology

authors： Del Giudice A,Aucella F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND METHODS:Smoking is associated with hyperparathyroidism in the elderly general population and nicotine, the main component of tobacco smoke, stimulates PTH release in experimental models. Although smoking is a persisting problem in patients with end-stage renal disease (ESRD), the association between smok...

journal_title：Journal of nephrology

authors： Tripepi G,Mattace-Raso F,Pizzini P,Cutrupi S,Witteman J,Zoccali C,Mallamaci F

更新日期：2012-01-01 00:00:00

abstract：:Gonadal dysfunction is a frequent finding in men with chronic kidney disease and with end-stage renal disease. Testosterone deficiency, usually accompanied by elevation of serum gonadotropin concentrations, is present in 26-66% of men with different degrees of renal failure. Uremia-associated hypogonadism is multifact...

journal_title：Journal of nephrology

authors： Iglesias P,Carrero JJ,Díez JJ

更新日期：2012-01-01 00:00:00

abstract：:Ferumoxytol is a new product approved for intravenous use by the US Food and Drug Administration (FDA) in the treatment of iron deficiency anemia in adults with chronic kidney disease. This approval was based on data from 3 open-label, randomized, controlled clinical trials. In all of these trials, ferumoxytol was wel...

journal_title：Journal of nephrology

authors： Kowalczyk M,Banach M,Rysz J

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Dialysate calcium (Ca) concentration should be viewed as part of the integrated therapeutic regimen to control renal osteodystrophy and maintain normal mineral metabolism. Thus, a correct ionized calcium mass balance (Ca++MB) during hemodialysis (HD) is crucial in the treatment of renal osteodystrophy. The G...

journal_title：Journal of nephrology

authors： Basile C,Libutti P,Di Turo AL,Tundo S,Maselli P,Casucci F,Losurdo N,Teutonico A,Vernaglione L,Lomonte C

更新日期：2011-11-01 00:00:00

abstract：:Chyluria results from an abnormal connection between lymphatic bed and urinary tract, causing lymph leakage into the urine. The clinical picture often begins with the appearance of cloudy, milky urines accompanied by monolateral flank pain, malnutrition, weight loss and weakness. We report a case of chyluria that occu...

journal_title：Journal of nephrology

authors： Graziani G,Cucchiari D,Verdesca S,Balzarini L,Montanelli A,Ponticelli C

更新日期：2011-09-01 00:00:00

abstract：:End-stage renal disease (ESRD) is a significant global health problem that places a considerable burden on health care resources. The leading cause of death in ESRD patients is cardiovascular disease, which is often preceded by changes in cardiac geometry, including left ventricular hypertrophy (LVH). Treatments that ...

journal_title：Journal of nephrology

authors： Culleton BF,Asola MR

更新日期：2011-07-01 00:00:00